| abstract |
The present invention relates to methods for treating nitrate-induced tolerancenin a mammal by administering a nitrate-induced tolerance treating amount of ancompound of formulae (I), (II), (III) (IV), (V), (VI), (VII), (VIII), (IX), (XA) or (XB) asndefined herein, or the pharmaceutically acceptable salts, prodrugs, polymorphs,nhydrates, solvates, active metabolites or stereoisomers thereof. The invention alsonrelates to pharmaceutical compositions for the treatment of nitrate-induced tolerancenin a mammal comprising a nitrate-induced tolerance treating amount of a compoundnof formulae (I), (II), (III) (lV), (V), (VI), (VII), (VIII), (IX), (XA) or (XB) as defined herein,nor the pharmaceutically acceptable salts, prodrugs, polymorphs, hydrates, solvates,nactive metabolites or stereoisomers thereof, and a pharmaceutically acceptablenvehicle, diluent or carrier. The invention further relates to methods of preventingnnitrate-induced tolerance in a mammal comprising administering a nitrate-inducedntolerance preventing amount of a cGMP PDE inhibitor. |