| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33168c56094caae6de7b1a144448fe54 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70539 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
1999-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa63dcc702b0d9aee605cb487f10fe4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed3d25c3a975f807f5c22a8ac4e432e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc430e5ac4b3a64658e71d4608097e10 |
| publicationDate |
2000-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1020519-A1 |
| titleOfInvention |
Minor histocompatibility antigens and their use in the diagnosis and treatment of tumors |
| abstract |
Human minor histocompatibility Ags (mHag) play an important'nrole in the induction of CTL reactivity against tumours afternHLA-identical allogeneic bone marrow transplantation (BMT).nAs most mHag are not tumour specific but also expressed bynnormal tissues, anti-tumour reactivity is often associatednwith life-threatening graft-versus-host disease (GVHD). Here,nwe describe the use of newly found tumour specific mHag fornthe development of novel means and methods for the treamentnof cancer. n In one example we identified a novel mHag, HB-1, that elicitsndonor-derived CTL reactivity in a B-cell acute lymphoblasticnleukemia (B-ALL) patient treated by HLA-matched BMT. Wenidentified the gene encoding the antigenic peptide recognisednby a HB-1 specific CTL. Expression of the HB-1 gene was onlynobserved in B-ALL cells and EBV-transformed B cells. Analysisnrevealed that the HB-1 gene is polymorphic. The restrictednexpression of the polymorphic HB-1 Ag by B-ALL cells was usednin one example of the invention to generate HB-1 specific CTLnin vitro using peptide-loaded dendritic cells. HB-1 specificnCTL against B-ALL were used to combat B-ALL and were shown tonat least in part reduce the growth of said leukemia withoutnevoking GVHD. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022223970-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0236750-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018505682-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03047606-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0236750-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018152633-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10414813-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03047606-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016127249-A1 |
| priorityDate |
1999-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |