http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1019440-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ab16aefd1a16fd1dc81a8c345d00919 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d5575a1af9fdadf1bb87b44b46951b4 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-81 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-81 |
filingDate | 1998-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25b43b8352f7f44c3856b409eceb1048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78b80c6d80b4003b6b6e9a5619632ffb |
publicationDate | 2000-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-1019440-A1 |
titleOfInvention | Bis-tetrameric hemoglobin and reagents for its production |
abstract | Cross-linking reagents for protein modification are provided, which comprise four functional, leaving groups capable of reacting with amino acid residues on the protein chains, one pair at each end of a relatively rigid chemical spacer group comprising aromatic residues joined by amide linkages. Such cross-linking reagents react with hemoglobin to effect intramolecular cross-linking of two dimeric hemoglobin units to stabilize the tetramers, by use of the respective pairs of functional groups, and to produce dimers of such tetrameric units, i.e. bis-tetrameric, intramolecularly cross-linked and stabilized hemoglobin, to the exclusion of higher molecular weight hemoglobin species. |
priorityDate | 1997-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 361.