http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1012265-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b33ece17e615b68506ed1317b2deaf4d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 |
| filingDate | 1998-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac649dd9f5b3c228e99a3371e245b45e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cdf4a1b46ccb71cef82248abc43f91e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7b744bfbd3b5ad7d2b125b69d9460d2 |
| publicationDate | 2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1012265-B1 |
| titleOfInvention | Repressed trans-activator system for characterization of protein-protein interactions |
| abstract | The invention provides a system for assaying protein-protein interactions. Amino acid sequences of interest are inserted into 'bait' and 'prey' fusion proteins. The bait fusion proteins include a DNA-binding domain. The prey fusion proteins include a transcriptional repression domain. The interaction of the bait and prey fusion proteins is detected by the repression of reporter genes. The reporter genes have operator sequences to which the DNA-binding domain of the bait fusion protein can bind. The reporter genes are expressed unless the prey fusion protein interacts with a bait fusion protein at the operator region of the reporter gene. When a prey fusion protein binds to a bait fusion protein, the expression of the reporter gene is repressed. Compounds that interfere with the interaction of bait and prey fusion proteins may be detected by their ability to reverse the repression of the reporter genes. |
| priorityDate | 1997-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.