http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1012152-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1fd34fea6801ea1d9286475b96be2d26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6584 |
| filingDate | 1998-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b380986feb3fad00ade30366f31744c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfeb10276a9a2c31d88bfe017d64a1c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268f8edf0110efe84639d0f384a902b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e79dfaebe21512feaccebe396028a8ef |
| publicationDate | 2000-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1012152-A1 |
| titleOfInvention | Method for preparing oxazaphosphorin-2-amines |
| abstract | The present invention relates to a method for preparing oxazaphosphorin-2-amines of the general formula (1), wherein R1 may represent H, 2-bromethyl, 2-chlorethyl, 2-hydroxyethyl, 2-mesyloxyethyl or 1-phenylethyl, R2 may represent H or 2-chlorethyl, R3 may represent H, 2-bromethyl, 2-chlorethyl or 1-phenylethyl and R4 may represent H. R1 and R2 as well as R3 and R4 may also form together with the linked N-atom a cyclic aziridin compound with the proviso that R1, R2 and R3 cannot represent simultaneously H and that R1 and R3 cannot represent simultaneously 1-phenylethyl. Y represent hydrogen hydrochloride or bromide or nothing. The compounds obtained using this new method are known drugs such as cyclophosphamide and ifosfamide which are used as cytostatic or immuno-suppressing agents. The amines (2) and (3) used as starting compounds are reacted during a single-vessel reaction with phosphoryl chloride and with an additional base used as an acid-fixation agent such as pyridine, triethylamine or alkaline or earth-alkaline carbonates. The reaction is carried out in the presence of inert solvents while reducing to a minimum the influence of water and without isolating an intermediate compound. |
| priorityDate | 1997-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.