| abstract |
The compounds are of the general formula (I):n nwhere Z is: -CO-, -CH(OR 6 )-, -C(NOR 7 )-; R 1 is: H, C 1 -C 6 alkyl, halogen, or -nOR 12 ; R 2 and R 3 are: H, alkyl, halogen, nitro or -OR 12 , or R 2 and R 3 togethernare -C(R 8 ) = C(R 9 )- C(R 10 ) = C(R 11 )-; R 4 and R 5 are: H, alkyl, halogen,nhaloalkyl, -OR 12 , nitro, NR 13 R 14 ; -COR 12 ; CO 2 R 12 ; -SO 2 NR 13 R 14 ; -SO 2 R 12 ;nSR 12 , cyano; -CONR 13 R 14 or R 4 and R 5 form a benzene ring; R 6 is: H, alkyl,nCO 2 R 12 , -C(O)NR 13 R 14 , naphthyl or phenyl; R 7 is: H or alkyl; R 8 , R 9 , R 10 andnR 11 are H, alkyl halogen, OR 12 , nitro, cyano, NR 13 R 14 , -COR 12 , CO 2 R 12 ; -nSO 2 NR 13 R 14 ; -SO 2 R 12 ; SR 12 , -CONR 13 R 14 ; R 12 is H, C 1 -C 6 alkyl or phenyl;nand R 13 and R 14 are H, alkyl or phenyl or R 13 and R 14 form a 5- or 6-memberednring. These compounds are effective for the treatment of anxietynor depression. |