| abstract |
A process of preparing thalidomide in which N-phthaloylglutamine or N-phthaloylisoglutaminenis cyclized with N,N'-carbonyldiimidazole, characterised in thatnthe process comprises heating said N-phthaloylglutamine or N-phthaloylisoglutaminenand N,N'-carbonyldiimidazole in refluxing anhydrous tetrahydrofuran. |