| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_269b0b2f24ff2790756289fa3ac1b9fd |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H11-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-33 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1998-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e79c9da7e0ab2fc639f8351a006df6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d103ce8ce9934bc8a7fbe57b0ba5f57 |
| publicationDate |
2003-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1003758-B1 |
| titleOfInvention |
Solution phase synthesis of oligonucleotides |
| abstract |
A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a coupling agent to form an H-phosphonate diester. The H-phosphonate diester is oxidised in situ with a sulfur transfer agent to produce the phosphorothioate triester. Preferably, the H-phosphonate and alcohol are protected nucleosides or oligonucleotides. Oligonucleotide H-phosphonates which can be used in the formation of phosphorothioate triesters are also provided. |
| priorityDate |
1997-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |