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filingDate 1995-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fb58b98dae7be8837a91081789f69c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_877a4d2c1deb3a3e97cba919d8982008
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publicationDate 2000-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1002529-A1
titleOfInvention Sustained-release preparation containing a metal salt of a peptide
abstract A sustained-release preparation containing a water-insolublenor slightly water-soluble polyvalent metal saltnof a water-soluble peptide type of physiologically activensubstance except for an endothelin antagonist and anbiodegradable polymer. nThe present invention is a sustained-release preparationnthat is highly efficient in incorporating a water-solublenpeptide type of physiologically active substance except fornan endothelin antagonist and suppresses initial burst ofnthe water-soluble peptide type of physiologically activensubstance except for an endothelin antagonist. Thensustained-release preparation of the present invention isncapable of releasing the water-soluble peptide type ofnphysiologically active substance except for an endothelinnantagonist while retaining its bioactivity afternadministration in vivo . Furthermore, the water-solublenpeptide type of physiologically active substance except fornan endothelin antagonist in the sustained-releasenpreparation is kept stable for a long period of time, withnlittle loss of bioactivity.
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priorityDate 1994-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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