| abstract |
Novel aromatic ring derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof. Because of having hypoglycemic and PDE 5 inhibitory activities, these compounds and salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complication of diabetes, insulin-resistant syndrome, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardio-vascular diseases, hyperglycemia, hypertension, angina pectoris, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal insufficiency, atherosclerosis, angiostenosis, peripheral vascular diseases, cerebral stroke, chronic reversible obstructive diseases, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by disordered intestinal motion, sexual impotence, nephritis, cachexia, pancreatitis, post-PTCA reconstriction, etc. In said formula (I), Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 represent each a cross-linking group; and A represents an aromatic ring. |