| abstract |
Non-replicating vectors, such as plasmid vectors, containing a nucleotide sequence coding for a G protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such vectors also may contain a further nucleotide sequence located adjacent to the RSV G protein encoding sequence to enhance the immunoprotective ability of the RSV G protein when expressed in vivo. Such non-replicating vectors may be used to immunize a host, including a human host, against RSV infection by administration thereto. Such non-replicating vectors also may be used to produce antibodies for detection of RSV infection in a sample. |