http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0989978-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 1998-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbd020e4f3502e0923617558abefe081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_802a09e283886f7ce8650525258cbb2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31727633548644eabe8083d4d543bb0d |
| publicationDate | 2000-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0989978-A1 |
| titleOfInvention | Tricyclic keto amide derivatives useful as farnesyl protein transferase inhibitors |
| abstract | Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R2 are halo; R1 and R3 are H and halo, provided that at least one of R1 and R3 is H; X is N, CH or C, when the double bond is present at the C-11 position; R4 is=O, -NHOH, -N=NHR6, -N=NHSO2R6, -N=NHCOR6, -N=NHCONH2, -N=NHCOCONH2, (H, OH), (H, -OR6), (H, -OCOR6), (H, OSO2R6) or -E-(CH2)n1-G-, wherein n1 is 1 to 5, and E and G are O, S or N, and are joined to the same carbon to form a cyclic structure; R5 is H, lower alkyl, or optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or heterocycloalkyl-alkyl; R6 is lower alkyl or optionally substituted aryl, heteroaryl, aralkyl, heteroaralkyl or heterocycloalkyl-alkyl; R7, R8 and R9 are independently selected from the group consisting of H, lower alkyl, aryl, and aralkyl; and n is 0-5. |
| priorityDate | 1997-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.