http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0988038-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1998-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a8b6bc6d2928aacc3277f84f740ddf3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddeaf0846be988ab98315acaf48014c5 |
| publicationDate | 2000-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0988038-A1 |
| titleOfInvention | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
| abstract | This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R<SUP>1 </SUP>is hydrogen, C<SUB>1-12</SUB>alkyl, Ar<SUP>1</SUP>, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyl, quinolinylC<SUB>1-6</SUB>alkyl, pyridylC<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, aminoC<SUB>1-6</SUB>alkyl, or a radical of formula -Alk<SUP>1</SUP>-C(-O)-R<SUP>9</SUP>, -Alk<SUP>1</SUP>-S(O)-R<SUP>9 </SUP>or -Alk<SUP>1</SUP>-S(O)<SUB>2</SUB>-R<SUP>9</SUP>; R<SUP>2</SUP>, R<SUP>3 </SUP>and R<SUP>16 </SUP>each independently are hydrogen, hydroxy, halo, cyano, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy, hydroxyC<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyloxy, aminoC<SUB>1-6</SUB>alkyloxy, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyloxy, Ar<SUP>1</SUP>, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyl, Ar<SUP>2</SUP>oxy, Ar<SUP>2</SUP>C<SUB>1-6</SUB>alkyloxy, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C<SUB>2-6</SUB>alkenyl; R<SUP>4 </SUP>and R<SUP>5 </SUP>each independently are hydrogen, halo, Ar<SUB>1</SUB>, C<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy, C<SUB>1-6</SUB>alkylthio, amino, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, C<SUB>1-6</SUB>alkylS(O)C<SUB>1-6</SUB>alkyl or C<SUB>1-6</SUB>alkylS(O)<SUB>2</SUB>C<SUB>1-6</SUB>alkyl; R<SUP>6 </SUP>and R<SUP>7 </SUP>each independently are hydrogen, halo, cyano, C<SUB>1-6</SUB>alkyl, 4,4-dimethyl-oxazolyl, C<SUB>1-6</SUB>alkyloxy or Ar<SUP>2</SUP>oxy; R<SUP>8 </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl, cyano, hydroxycarbonyl, C<SUB>1-6</SUB>alkyloxycarbonyl, C<SUB>1-6</SUB>alkylcarbonylC<SUB>1-6</SUB>alkyl, cyanoC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxycarbonylC<SUB>1-6</SUB>alkyl, carboxyC<SUB>1-6</SUB>alkyl, hydroxyC<SUB>1-6</SUB>alkyl, aminoC<SUB>1-6</SUB>alkyl, mono- or di(C<SUB>1-6</SUB>alkyl)aminoC<SUB>1-6</SUB>alkyl, imidazolyl, haloC<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxyC<SUB>1-6</SUB>alkyl, aminocarbonylC<SUB>1-6</SUB>alkyl, or a radical of formula -O-R<SUP>10</SUP>, -S-R<SUP>10</SUP>, -N-R<SUP>11</SUP>R<SUP>12</SUP>; R<SUP>17 </SUP>is hydrogen, halo, cyano, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxycarbonyl, Ar<SUB>1</SUB>; R<SUP>18 </SUP>is hydrogen, C<SUB>1-6</SUB>alkyl, C<SUB>1-6</SUB>alkyloxy or halo; R<SUP>19 </SUP>is hydrogen or C<SUB>1-6</SUB>alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation. |
| priorityDate | 1997-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 481.