http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0987264-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_620ecb9324409347c27e96b6071503ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 1998-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0e775111deb655e13b20571aa9a8c95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95223062c074c09d8d8ef3e0800fc639 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca43da55c0d8da24f3439a06db74c69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6be81333b8bc8068c49151ad71ff70c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83f76d96502b0362e37cf469a444f2ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba253dda07ae3f63d82d3c332af65177 |
| publicationDate | 2000-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0987264-A1 |
| titleOfInvention | 4,4-difluoro-2,3,4,5-tetrahydro-1h-1-benzazepine derivatives and drug compositions containing them |
| abstract | 4,4-Difluoro-2,3,4,5-tetrahydro-1 H -1-benzazepinenderivatives represented by the following formula (I) or saltsnthereof:n n(wherein each of the symbols has the following meaning:n ring A: a 5-membered heteroarylene group; ring B: an optionally substituted aryl group or a 5- ton6-membered heteroaryl group; D: a carbonyl group or a lower alkylene group; R 1 : a group represented by formula, NR 3 R 4 , an -O-lowernalkyl group, or OH; R 2 : an optionally halogen atom-substituted lower alkylngroup, an -O-lower alkyl group, an -S-lower alkyl group, or an-CO-lower alkyl group; R 3 , R 4 : same or different and each isn 1) a hydrogen atom, 2) a lower alkyl group (the lower alkyl group may bensubstituted with OH, an optionally protected amino group, annoptionally protected mono-lower alkylamino group, a di-lowernalkylamino group, an optionally lower alkyl group-substitutedn5- to 7-membered saturated heterocyclic group, a 5- to 6-memberednheteroaryl group, or an aryl group), 3) a cycloalkyl group, 4) an optionally lower alkyl group-substituted 5- ton7-membered saturated heterocyclic group, 5) a 5- to 6-membered heteroaryl group, 6) an aryl group, or 7) an optionally substituted 5- to 7-memberednnitrogen-containing heterocyclic group formed by integrationnof the formula, NR 3 R 4 (the 5- to 7-membered nitrogen-containingnheterocyclic group may be fused with a benzene ring or with an5- to 6-membered heteroaryl group);n(in the 5- to 7-membered saturated heterocyclic group, the 5-ton7-membered nitrogen-containing heterocyclic group and then5- to 6-membered heteroaryl group in the above 2), 4), 5) andn7), a group having a cyclic secondary amine may be one whereinnthe amine is protected); and n: 0, 1 or 2.) n The compounds of the present invention exhibit thenoxytocin antagonism and are effective in inhibiting threatened npremature birth or abortion, or precesarean birth and usefulnas remedies for dysmenorrhea and so. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807664-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8343976-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2341776-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2341776-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8518934-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03016316-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8563732-B2 |
| priorityDate | 1997-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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