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filingDate 1998-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40913f0aedc7ad367daf570587c8753e
publicationDate 2002-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0986394-B1
titleOfInvention Anti-coagulation of blood, blood plasma or synovial fluid products
abstract A method of anti-coagulating a blood, blood plasma or synovial fluid product comprising addition to the product iso-citrate is described. The method may further comprise adjustment of the calcium ion activity of the anti-coagulated product to physiological levels with a soluble calcium salt. Blood, blood plasma or synovial fluid products containing an anti-coagulating amount of anti-coagulant comprising iso-citrate, and optionally citrate, is disclosed. These anti-coagulated products are used for transport and storage of the products and/or for analysis of hemostatic or coagulative properties of the products. Additionally, blood sampling containers comprising isotonic or slightly hypertonic solutions of iso-citrate, and blood sampling containers comprising a solution of 0.1-0.5 M iso-citrate in one tenth of the container volume, and optionally an effective amount of calcium chloride resulting in a calcium ion activity of approximately 1 mM, are disclosed. Finally, reagents for analysis of blood, blood plasma or synovial fluid products comprising iso-citrate are described.
priorityDate 1997-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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