| abstract |
Aminophenol derivatives represented by the followingnformula (1):n nwherein X is O or S; A is alkylene, R 1 is phenyl, etc., R 2 nand R 3 are H or alkyl; R 4 is substituted carbamoylalkyl,netc.; R 5 is substituted amino, etc.; their salts, andnoptical isomers of the derivatives and salts. Alsondisclosed are gastrin receptor antagonists, cholecystokininnreceptor antagonists, and medicines for digestive diseases.nThe compounds have strong binding inhibition against gastrinnreceptor or CCK-A receptor and also they have highernselectivity to either group of CCK-A receptor or gastrinnreceptor, and therefore, the compounds are useful fornpreventing and treating gastrointestinal diseases includingnpeptic ulcers as well as central nervous system diseases. |