http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0983373-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5e07888f923b7443f3b8eb913614893 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62 |
filingDate | 1999-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff05c27a842ad52eda1a661f4fe32704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdac20b6aedc5ca8f3461e47cdecf349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_206c79f98a466760d09cd60c58fdf31d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd4128cdf1e68c98e1c5947ebd10c90 |
publicationDate | 2000-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0983373-A1 |
titleOfInvention | Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
abstract | A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, including: a) cultivating a microorganism biomass in the seed culture stage to produce an inoculum; b) transferring the inoculum into a fermentation medium in the main fermentation stage; and, c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing mevinolin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-300153-B6 |
priorityDate | 1998-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 116.