| abstract |
The invention relates to a process for the selective oxidation of primary alcohols ofnoligosaccharides to form the corresponding carboxylic acid derivatives of the alcohols usingncatalytic amounts of a di-tertiary-alkyl nitroxyl free radical, characterized in that 1,3-dibromo-5,5-dimethylhydantoinnor 1,3-dichloro-5,5-dimethylhydantoin is used as oxidant and the reactionnis performed in neutral to basic conditions at a pH < 10. nThe process of the invention is useful for the production of (partially protected)noligosaccharides comprising carboxylate groups, both intermediates and end products. |