http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0977740-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebb6a553affdc364c91cffe3baf12564 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-66 |
| filingDate | 1998-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ac5414785e5db896dbfb95b484940cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a63550f7b7bca5932a200ef48d02e6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc8612094babedbdd74ce41b99cb7c9d |
| publicationDate | 2001-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0977740-A4 |
| titleOfInvention | METHODS OF SYNTHESIS OF 2-SUBSTITUTED IMIDAZOLES |
| abstract | The present invention is a method of preparing 2-substituted imidazoles from readily available imidazoles having a leaving group in the 2-position, by alkylating the imidazole under mild conditions to afford a 3-N-alkylated imidazolium salt; and coupling the imidazolium salt with a nucleophile also under mild conditions to afford a 2-substituted 3-N-alkylated imidazolium salt. The reaction product can optionally be isolated and purified. The 2-substituted 3-N-alkylated imidazolium salt is hydrolyzed to afford a 2-substituted imidazole. Alternatively, the imidazole is coupled with a nucleophile in the presence of fluoride ion to provide a 2-substituted imidazole. |
| priorityDate | 1997-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 321.