| abstract |
A vaccine is disclosed which is useful for protecting a hostnfrom Gram negative infections and the effects of endotoxin,ntherefore preventing sepsis and septic shock. The vaccine isnprepared by combining LPS free or in conjugate form with anstoichiometric excess of a peptide of the formula:n (a) (A) n wherein A is Lysine or Arginine and n is an integernwith a minimum value of 7; (b) (AB) m wherein A is Lysine or Arginine and B is anhydrophobic amino acid selected from the group consisting ofnValine, Leucine, Isoleucine, Tyrosine, Phenylalanine andnTryptophan; m is an integer with a minimum value of 3; and (c)n(ABC) p wherein A is a cationic amino acid which is Lysine ornArginine; B and C are hydrophobic amino acids which may be thensame or different and are selected from the group consistingnof Valine, Leucine, Isoleucine, Tyrosine, Phenylalanine andnTryptophan; p is an integer with a minimum value of 2. |