http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0975597-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df874e3cf88adba3792dc9d5b5776180 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
| filingDate | 1998-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a084f872e667d58d84a6174413631c60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a3bbe262e261405e75813abcd29919 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd922d077a758dba88e9cc1c09e7570e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cedddd077e25810c6107d03dd63b1ebb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7efb2f4cbf5323c58fd49f46f2a74d8c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_432ccf71064cae5a984104b589e96ffe |
| publicationDate | 2009-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0975597-B1 |
| titleOfInvention | Quinoline derivatives, having in particular antiviral properties, preparation and biological applications thereof |
| abstract | The invention concerns quinoline derivatives of formula (I) in which: Ra, Rb and Rc, identical or different represent one or several substituents, themselves identical or different, in any position on the cycles, this or these substituents being selected among a -(CH2)n -Y or -CH = CH-Y group, in which Y is halogen, -OH, -OR, -COH, -COR, -COOH, -COOR, -COH, -COR, -CONH2, -CON(Rx, Ry) -CH = NOH, -CO- -CH = NOH, -NH2, -N(Rx, Ry), -NO2, -PO(OR)2-SH2, -SR, -SO2R, -SO2NHR, CN, or Z(Rc) in which R is a C1-C8 alkyl, or aryl or a heterocyclic compound, Rx and Ry, identical or different are C1-C5 alkyl, Z an aryl or heterocyclic compound and n is nil or a whole number between 1 and 5, Rb can further represent a hydrogen, and when Y is -COOH or -COOR in Rc, Z, if it represents an aryl, comprises at least 3 substituents or the quinoline ring is trisubstituted; X is an ethylene double bond; a -(CH2)n- group in which n is a whole number between 1 and 5: or a -CH(Rd)-CH(Re) group, Rd and Re, identical or different, representing a hydrogen, a halogen, hydroxy or epoxy; or a -(CH2)n, -O-C-(CH2)m-, -(CH2)n, -C(O)-O-(CH2)m, -(CH2)n, -O-(CH2)m-, -(CH2)n, -N(Q)-(CH2)m-, or -(CH2)n, -S(O)t-(CH2)m-, group, in which n = 1 to 8, m = 0 to 8, t = 0, 1 or 2, and Q = H, aryl or alkyl. The invention also concerns the pharmaceutically acceptable salts of these derivatives, the diastereoisomeric and the enantiomeric forms thereof. The invention is useful as medicines with HIV anti-integrase inhibiting effect. |
| priorityDate | 1997-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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