| abstract |
Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly 'loop grafting' to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity e.g. platelet adhesion to fibrinogen in addition to possessing one or more further biological or biochemical activities not native to dendroaspin, e.g. platelet derived growth factor (PDGF) activity or hirudin activity. |