| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78587acbfc8d4c9e9ac3baa7021087d7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e26de8d88c7b32804d869e560ae6ac52 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-151 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1132 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate |
1998-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c39735f40669aeaa92188189611cb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1117522b8de85f234475c5bf25ba3b0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5addc0c6e6c793dc924059b1647776b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a44a115607865b86805c83582e81439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4b1280a6f14f18be3931218fd690873 |
| publicationDate |
2000-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0971944-A1 |
| titleOfInvention |
Anti-viral guanosine-rich tetrad forming oligonucleotides |
| abstract |
Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed. |
| priorityDate |
1997-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |