| abstract |
New 17α-fluoralkyl steroids have general formula (I), in which R1 stands for a methyl or ethyl group; R2 for a radical of formula C¿n?FmHo, in which n equals 2, 3, 4, 5 or 6, m⊃1 and m+o = 2n+1; R?3¿ stands for a free, etherified or esterified hydroxy group; R?4 and R5¿ stand each for a hydrogen atom, or together for an additional bond or a methylene group; St stands for a steroidal ABC ring system of partial formulas (A), (B) or (C), in which R6 stands for a hydrogen atom, a straight chain C¿1?-C4- or branched chain C3-C4-alkyl group or a halogen atom; R?7¿ stands for a hydrogen atom, a straight chain C¿1?-C4- or branched chain C3-C4-alkyl group or, when St stands for a steroidal ABC ring system of formulas (A) or (B), R?6 and R7¿ can form together an additional bond; X stands for an oxygen atom, an hydroxyimino group =N∩OH or two hydrogen atoms; R8 stands for a radical Y or for an aryl radical optionally substituted several times with a group Y, in which Y stands for a hydrogen atom, a halogen atom, an -OH, -NO¿2?, -N3, -CN, -NR?9aR9b¿, -NHSO¿2?R?9, -CO¿2R9, C1-C10-alkyl, C1-C10-alkoxy, C1-C10-alcanoyloxy, benzoyloxy, C1-C10-alkanoyl, C1-C10-hydroxyalkyl or benzoyl group, and R?9a and R9b¿ are the same or different and like R9 represent a hydrogen atom or a C¿1?-C10-alkyl group. Also disclosed are the physiologically admissible salts of these steroids with acids, when they contain the radicals NR?9aR9b¿, and their physiologically admissible salts with bases, when they contain the radicals -CO¿2R?9, in which R9 stands for hydrogen. These new compounds display an extraordinarily strong antigestagenic activity and are suitable for preparing pharmaceutical compositions. |