| abstract |
Nifedipine, optionally in combination with bethanechol, is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and haemorrhoids. The agents induce a reduction in the mean and resting pressure, thereby assisting in the healing of anal fissures and haemorrhoids. Optionally, the active agents may be co-administered with a steroid, such as hydrocortisone. |