| abstract |
The present invention relates to compounds of the general formulan nwhereinn R 1 is C 6 - 10 -cycloalkyl, optionally substituted by lower alkyl or -C(O)O-lowernalkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl;nindan-1-yl or indan-2-yl, optionally substituted by lower alkyl;ndecahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl;n2,3,3a,4,5,6-hexahydro-1H-phenalen-1-ylnor octahydro-inden-2-yl; R 2 is hydrogen; lower alkyl; =O or phenyl, optionally substituted bynlower alkyl, halogen or alkoxy; A ○ is cyclohexyl or phenyl, optionally substituted by lower alkyl,nhalogen or alkoxy; X is -CH(OH)-; -C(O)-; -CHR 3 -; -CR 3 =; -O-; -S-; -CH(COOR 4 )- or -nC(COOR 4 )=; Y is -CH 2 -; -CH=; -CH(COOR 4 )-, -C(COOR 4 )=; or -C(CN)-; R 3 is hydrogen or lower alkoxy; R 4 is lower alkyl, cycloalkyl, phenyl, or benzyl nand neither a or b is optionally an additional bond, nand to pharmaceutically acceptable acid addition salts thereof. n The compounds are agonists and/or antagonists of the orphanin FQn(QFQ) receptor and therefore useful in the treatment of diseases, related tonthis receptor. |