| abstract |
Assembly for an automated and simultaneous chemical synthesis and facultative purification of solid products, has a number of separate reaction vessels or reactors which are open at the top and bottom, and are assembled into a reactor block using 10-100 vessels (especially 48). They form a number of columns (especially small columns), which can be removed separately or together. The carrier material for the synthesis is inserted into the channels or columns either between two inert and porous chips beds or as chemically-modified chip or filter beds, so that a fluid medium passed in from above can be held only by surface tension and saturation of the carrier material, with an inert gas supply if required. Also claimed is a process using linkers for a covalent linking of the product with the carrier, to give a selective and effective abstraction of the product. A universal linker can be used especially for the synthesis of materials such as oligonucleotides or peptides, where the components for the initial structural reaction can be linked with the same chemical type, which can be used for further structural reactions. A linker class of only one type of components can be used for the whole synthesis, especially only a nucleoside-3'-phosphoramidite for the synthesis of 3'-OH-oligonucleotides. |