| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5976ba69a401cf70e6f8d1978e47a82 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-24 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C25B-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C25B7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C25B3-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
1999-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2002-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7e8f20d986518017e819a346bf91382
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d4d23ea126a67364a88717e422e6f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eb2d2f34f930abebc9f8d39d3d9be1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2eb36843b70045988e79ca550748484 |
| publicationDate |
2002-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0962552-B1 |
| titleOfInvention |
A process for the preparation of 4-(des-dimethylamino)-tetracyclines |
| abstract |
The present invention refers to a process for the preparation of 4-(desdimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(desdimethylamino)-tetracyclines are isolated by extraction with an organic solvent. |
| priorityDate |
1998-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |