| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb78b459e21bb4fd52850a12cab27387 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-16 |
| filingDate |
1999-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5be37948d6e03e867994ba91930af14e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b497098c774aa42e443b5da5b841350 |
| publicationDate |
1999-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0955291-A1 |
| titleOfInvention |
Preparation of 2-substituted pyridines |
| abstract |
This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to provide the desired 2-substituted pyridine. The substitution of sec-butyllithium for n-butyllithium in such a process results in an enhanced yield and purity of the desired 2-substituted pyridine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7022857-B2 |
| priorityDate |
1998-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |