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filingDate 1999-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1999-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0953632-A1
titleOfInvention Use of nanoemulsions for determination of the biocompatibility of lipophilic materials in cell culture test and nanoemulsions suitable therefor
abstract Nanoemulsions are used to determine the cell toxicity of lipophilicnSubstances in cell culture test; to determine the genotoxicity of lipophilic substancesnin the cell culture test; for the biotransformation of lipophilic substances with cell cultures; tonPromotion of cell differentiation from primary cell cultures; to complementncell culture media with lipophilic substances that promote cell growth;nto complement cell culture media with lipophilic substances, which thenPromote biosynthesis of desired substances in the cells; as well as targeted andnreproducible introduction of lipophilic substances into the cells of cell cultures.nPreferred are nanoemulsions in which: the oil particles have a diameternless than 100 nm; the occupation of the oil particles with the amphotericnEmulsifier is single-layer on its surface; the oil particles one to be examinednor contain dissolved substance to be released to the cell culture; and both the oil particles,nthe substance dissolved in it and the aqueous phase are germ-free.
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