| abstract |
A method for making a biocompatible medical article, and preferably, anblood compatible medical article, through the use of a copolymer coating. The copolymerncoating is synthesized using methacrylate or acrylate monomers with a functional groupn(primary amino group) for subsequent attachment of a biomolecule such as heparin.nSynthesis of the copolymer coating is carried out using the proper proportion ofnhydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize thensolubility of the copolymer in alcohol, its insolubility in water (before and after heparinncoupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymerncoating is fashioned, a medical article is coated with it. The coating is thereafter dried andnthe biomolecule, such as heparin, attached. In such a manner the present inventionnprovides for a method for making a biocompatible medical article, and preferably, a bloodncompatible medical article. |