| abstract |
A pharmaceutical composition of a hedgehog protein which is characterized in thatnthe hedgehog protein is bound to a hydrophilic carrier that is biocompatible andnbiodegradable wherein the carrier is a polymer whichn binds the hedgehog protein as a negatively-charged carrier as a result ofnionic interactions, does not denature the hedgehog protein when it binds to the carrier, contains at least 0.1 to 2 negatively-charged residues per monomer undernneutral conditions, contains the charge in the form of acidic groups, has an average molecular weight of at least 50,000 Da and contains no agarose nreversibly and actively releases hedgehog proteins in vivo from a carrier in a delayednmanner. |