| abstract |
An erythromycin A derivative represented bynFormula (I):n n[wherein n is an integer of from 1 to 4, R 1 is a groupnrepresented by the formula:n na group represented by the formula:n na pyridylacetyl group, a cycloalkylmethyl group having 4nto 8 carbon atoms or a 1,2-bis(ethoxycarbonyl)vinylngroup, R 2 is the same group as defined for R 1 , anhydrogen atom, an alkyl group having 1 to 5 carbon natoms, an alkanoyl group having 2 to 6 carbon atoms ornan alkoxycarbonyl group having 2 to 6 carbon atoms, R 1 nand R 2 together form a group of the formula: =CH-R 14 , ornR 1 and R 2 together with the nitrogen atom to which theynare attached form a group represented by the formula:n nR 15 and R 16 are each a hydrogen atom or when W is ancarbon atom, R 15 and R 16 together with the carbon atomsnto which they are attached form a benzene ring or annaphthalene ring, R 3 is a hydrogen atom, an alkyl groupnhaving 1 to 5 carbon atoms or a cinnamyl group, R 4 is anhydrogen atom, an acetyl group, an ethylsuccinyl groupnor a nicotinoyl group, A is a group represented by thenformula: n-OC(=O)-R 17 , -OC(=O)-CH 2 -R 17 , -OC(=O)-NH-R 17 , -O-R 17 orn-OC(=O)-O-R 17 , and R 5 and R 6 are each a hydrogen atom ornan alkyl group having 1 to 5 carbon atoms] or anpharmaceutically acceptable salt thereof has a strongnantibacterial activity against not only against knownnerythromycin-sensitive bacteria but also erythromycin-resistantnbacteria. |