| abstract |
The present invention relates to a powdery composition for nasalnadministration, which is characterized in thatn (1) the composition contains (i) a drug, (ii) a water-absorbing andngel-forming base material such as hydroxypropyl cellulose ornhydroxypropylmethyl cellulose and (iii) a water-absorbing and water-insolublenbase material such as crystalline cellulose or α-cellulose, (2) wherein the amount of the water-absorbing and gel-forming basenmaterial is about 5-40 wt % based on the total of the water-absorbingnand gel-forming base material and the water-absorbing and water-insolublenbase material, and (3) wherein the drug is unevenly dispersed more on/in the water-absorbingnand water-insoluble base material than on/in the water-absorbingnand gel-forming base material. n The present invention provides the powdery composition fornnasal administration excellent in absorption of the drug from the nasalncavity and having an extremely increased maximum blood concentrationncomparing a conventional composition for nasal administration even forna drug having a high solubility in water, a drug having a high lipophilicitynor a peptide/proteinaceous drug having a large molecular weight. |