http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0937714-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 1999-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b934e483f16a3ca940e2acee80afcb73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6a5b2ba150e038a9eaddc4c8bd9c661 |
| publicationDate | 1999-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0937714-A1 |
| titleOfInvention | Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof |
| abstract | Process for the preparation of an opticallynactive N-acyl-indoline-2-carboxylic acid in which anmixture of enantiomers of N-acyl-indoline-2-carboxylicnacid is contacted with an optically active resolvingnagent and the optically active N-acyl-indoline-2-carboxylicnacid is liberated from the resultingndiastereomeric salt, as resolving agent use being madenof a compound of formula 1, where R 1 represents annalkyl group and R 2 a (hetero) aryl group or where R 1 andnR 2 together with the C atoms to which they are boundnform a cycloalkyl group with 5-8 C atoms, fused with an(hetero) aryl group. Preferably, a mixture ofnenantiomers of an N-acyl-indoline-2-carboxylic acid isnprepared in a process comprising the steps of Fischernindole cyclization of a 2-phenylhydrazone propionicnacid or a derivative thereof in the presence of an acidncatalyst, if necessary hydrolysis of the derivative tonthe corresponding acid, acylation at the N-position andnreduction of the indole compound to the correspondingnindoline compound, after which the resulting N-acyl-indoline-2-carboxylicnacid is subjected to thenresolution. The 2-phenylhydrazonopropionic acid or anderivative thereof is preferably obtained fromnphenylhydrazine and pyruvic acid or the correspondingnderivative thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1676838-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1338591-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1792896-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7405070-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-007948-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7157484-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004218202-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0194334-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2004218200-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004078707-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100364974-C http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004078707-A3 |
| priorityDate | 1998-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 161.