http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0935596-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dbc8af1157a8bba7d30d053437b371 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b459ec3f5254c20ccd5ca24931c4610 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 1997-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5b81490a5afc41e92262fdaeb437046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a154a30a6d83e6622da07343ccad2a |
| publicationDate | 1999-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0935596-A4 |
| titleOfInvention | METHOD FOR PRODUCING PACLITAXEL |
| abstract | A method for producing paclitaxel is accomplished by first esterifying C-7-CBZ baccatin III with a C3'-N-CBZ-C2'-O-protected (2R, 3S)-3-phenylisoserine side chain to form a first intermediate. Next, the carbobenzyloxy groups at C-7 and at the C3' nitrogen site of the first intermediate are respectively replaced with hydrogen and PhCO to produce a second intermediate that is next deprotected at C2' by replacing the protecting group with hydrogen. The C2' protecting group is a benzyl-type protecting group, preferably benzyloxymethyl or benzyl. Excess amounts, such as six equivalents, of the side chain are preferably employed. DMAP and a dialkylcarbodiimide are also preferably used during esterification. Various preferred reaction temperatures, times, and purification steps are disclosed. |
| priorityDate | 1996-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.