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filingDate 1997-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2005-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d67cc098a42eeef45e5e61780667c6c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52fc881e027e781932e4dcba9c3adde
publicationDate 2005-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0935470-B1
titleOfInvention Method for treating allergic lung disease
abstract The invention is directed to a method for treating both the early and late phases of allergic asthma by introducing naked polynucleotides which operatively encode for the asthma-initiating antigen into the host. The antigen-encoding polynucleotides are administered to host tissues which contain a high concentration of antigen presenting cells (e.g., skin and mucosa) relative to other host tissues. Expression of the asthma-initiating antigen encoding polynucleotides of the invention inside of antigen presenting cells (without substantial secretion therefrom) induces antigen tolerance while suppressing IgE antibody formation in the early phase of the disease, and also suppresses cytokine-mediated eosinophil accumulation in the late phase of the disease. Devices and compositions for use in the methods of the invention are also described.
priorityDate 1996-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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