http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0934745-B1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24ce2ecfefe8e997ca7a1fb6f98bafc9 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
filingDate | 1999-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2004-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd239b8893f2007f06a1be04b0a8bc6b |
publicationDate | 2004-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0934745-B1 |
titleOfInvention | Use of androsterone derivatives for inhibiting DNA binding of ap-1 and airway smooth muscle proliferation |
abstract | There is described a method for the use of the adrenal steroid dehydroepiandrosterone and certain of its analogs to reduce growth of immortalized and malignant cell lines, according to the following formula: <CHEM> and <CHEM> wherein X is halogen, hydroxy, hydrogen, lower alkyl or lower alkoxy; Y is hydrogen or hydroxy; Z is lower alkyl or hydrogen. Dehydroepiandrosterone and its potent analogs 16 alpha -bromo-5-andtosten-17-one, 16 beta -bromo-5-androsten-17-one, 16 alpha -fluoro-5-androsten-17-one, 16 beta -fluoro-5-androsten-17-one, 16 alpha -bromo-5-androstan-17-one, 16 beta -bromo-5-androstan-17-one, 16 alpha -fluoro-5-androstan-17-one and 16 beta -fluoro-5-androstan-17-one impair activation of secondary growth response genes, and thus prove useful for the preparation of medicaments for the treatment of asthmatic airway remodelling in man. |
priorityDate | 1998-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 758.