| abstract |
There is described a method for the use of the adrenal steroidndehydroepiandrosterone and certain of its analogs to reduce growth ofnimmortalized and malignant cell lines, according to the following formula:n n andn nwhereinn X is halogen, hydroxy, hydrogen, lower alkyl or lower alkoxy; Y is hydrogen or hydroxy; Z is lower alkyl or hydrogen. n Dehydroepiandrosterone and its potent analogs 16α-bromo-5-andtosten-17-one,n16β-bromo-5-androsten-17-one, 16α-fluoro-5-androsten-17-one, 16β-fluoro-5-androsten-17-one,n16α-bromo-5-androstan-17-one, 16β-bromo-5-androstan-17-one,n16α-fluoro-5-androstan-17-one and 16β-fluoro-5-androstan-17-onenimpair activation of secondary growth response genes, andnthus prove useful for the preparation of medicaments for the treatment ofnasthmatic airway remodelling in man. |