| abstract |
An inverse filtration head (2, 202, 60, 104) and an apparatus including the filtration head are provided for use in solid phase chemical synthesis methods, such as in the synthesis of polypeptides, peptoids, polynucleotides and other molecules synthesized by solid phase techniques. The inverse filtration head (2, 202, 60, 104) includes a plurality of influent/effluent conduit pairs (4, 204) arranged in a substantially parallel array. The conduit pairs (4, 204) are used to simultaneously aspirate and/or wash and fill a plurality of reaction vessels arranged in a corresponding order array. An inverse filtration device (52) is also provided. The filtration device (52) includes an inverse filtration head (2, 202, 60, 104) and a control panel (106) which allows actuation of associated gas, fluids and vacuum delivery means for delivery to and from the filtration head (2, 202, 60, 104). An inverse filtration apparatus (102) is provided which includes the inverse filtration device (52), a valve box (108) and associated fluid (130, 134), gas and vacuum sources (132). |