| abstract |
A process for preparation of 3-amino-2-hydroxy-1-propylnether of the formulan nwherein R 1 is substituted or unsubstituted alkyl,nsubstituted or unsubstituted aryl, or substituted ornunsubstituted heterocyclic ring, R 2 and R 3 are the same orndifferent hydrogen atom, a substituted or unsubstitutednalkyl, or may form a ring together with an adjacentnnitrogen atom, which ring may be interrupted with nitrogennatom, oxygen atom or sulfur atom, nwhich is characterized in reacting an epoxy compound of thenformulan nwherein X is halogen, nin the presence of a fluoride salt, with an alcohol andnthen reacting an amine. n According to the above method, an intermediates fornsynthesis of medicines is obtained in good yield and highlynoptical purity. |