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filingDate 1996-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0edb99eecd03ae86ad4c144e2dc9c03f
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publicationDate 1999-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0929809-A1
titleOfInvention Process and device for in vitro diagnosis of allergic disorders
abstract PCT No. PCT/EP96/05501 Sec. 371 Date Sep. 3, 1998 Sec. 102(e) Date Sep. 3, 1998 PCT Filed Dec. 9, 1996 PCT Pub. No. WO97/22002 PCT Pub. Date Jun. 19, 1997The invention relates to a process for the in vitro diagnosis of allergic, in particular also pseudo-allergic, immunological and environment-related disorders using live biopsy tissue samples. Also disclosed is a mobile incubation device for keeping the tissue samples alive and functioning. The samples can be, for example, skin or mucous membrane particles. The biopsy sample (14) once removed from the patient is placed in a temperature-controlled oxygen-containing incubating medium (16) and an allergen is introduced, triggering an immediate reaction (a so-called type 1 allergy). The secretion of immunoglobulin E (IgE) or a mediator is then determined qualitatively and/or quantitatively. Suitable mediators are histamine, tryptase, ECP, MPO, DAO, TPS, interleukins, prostaglandins or cytokines. The proposed mobile incubation device is provided with a temperature-controllable incubator for sample holders inside a housing. The sample containers can be filled with a nutrient solution. An oxygen-containing fluid is bubbled through feed ducts into the nutrient solution.
priorityDate 1995-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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