| abstract |
6-Phenyltetrahydro-1,3-oxazin-2-one derivatives represented by general formula (I) and having a phosphodiesterase IV inhibitory effect, optically active substances thereof, pharmacologically acceptable salts thereof or their hydrates or solvates, and medicinal compositions containing the same, in particular preventives or remedies for inflammatory diseases and antiasthmatics, wherein R1 represents optionally substituted C1-8 alkyl, optionally substituted C3-7 cycloalkyl, etc.; R2 represents C1-4 alkyl; R3 represents H, optionally substituted C1-5 alkyl, etc.; R4 represents H or optionally substituted C1-6 alkyl; and R5 and R6 independently represent each H, optionally substituted C1-5 alkyl, etc.. These derivatives have potent effects of inhibiting phosphodiesterase (PDE) IV and bronchodilating and antiinflammatory effects. |