| abstract |
The present invention provides a compound of the formula (I):n nwherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen, optionally substitutednalkyl, hydroxy, optionally substituted alkoxy or the like, R 5 is optionally substitutednalkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R 6 isnhydrogen, optionally substituted alkyl or the like, R 7 is hydrogen, optionallynsubstituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionallynsubstituted heterocyclic or the like, A is S or O and a broken line represents presencenor absence of a bond, npharmaceutically acceptable salt or hydrate thereof and a pharmaceutical compositionnor a pharmaceutical composition for use as an endothelin receptor antagonist, anperipheral circulation insufficiency-improving agent or a macrophage foam cellnformation inhibitor comprising the compound. |