| abstract |
A class of pyrazolyl benzenesulfonamide compoundsnis described for use in treating inflammation andninflammation-related disorders. Compounds of particularninterest are defined by Formula II:n n wherein R 2 is selected from hydrido, alkyl, haloalkyl,nalkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl,nalkylaminocarbonyl, cycloalkylaminocarbonyl,narylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl,naralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl,nalkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R 3 isnselected from hydrido, alkyl, cyano, hydroxyalkyl,ncycloalkyl, alkylsulfonyl and halo; and wherein R 4 isnselected from aralkenyl, aryl, cycloalkyl, cycloalkenyl andnheterocyclic; wherein R 4 is optionally substituted at ansubstitutable position with one or more radicals selectednfrom halo, alkylthio, alkylsulfonyl, cyano, nitro,nhaloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl,ncarboxyl, cycloalkyl, alkylamino, dialkylamino,nalkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy,nsulfamyl, heterocyclic and amino; provided R 2 and R 3 arennot both hydrido; further provided that R 2 is not carboxylnor methyl when R 3 is hydrido and when R 4 is phenyl; furthernprovided that R 4 is not triazolyl when R 2 is methyl; further provided that R 4 is not aralkenyl when R 2 isncarboxyl, aminocarbonyl or ethoxycarbonyl; further providednthat R 4 is not phenyl when R 2 is methyl and R 3 is carboxyl;nand further provided that R 4 is not unsubstituted thienylnwhen R 2 is trifluoromethyl; or a pharmaceutically-acceptablensalt thereof. |