| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8603ee14f13e9c3d3f6d5858bf4f3bf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 |
| filingDate |
1997-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_440c1c0d322b44b6751a0d642f1c8350
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_762471b4ca5c8290b035f9e09c0e4003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ced5a97fe4ea71b06acdcdf417ab6196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecc719557dba036de63fa63164d449f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_100d9c67b2c4e0479b3a4032a52991d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27e77bd0fbd0b64ed123d58655ff4661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea5c58553d09f1366314b6695620d655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90af91a2b108e007467cb8ad9fa5271d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48d62924fcf327367d9aedcffe000acb |
| publicationDate |
1999-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0923565-A1 |
| titleOfInvention |
Process for preparing paclitaxel |
| abstract |
The present invention relates to a process for preparing paclitaxel represented by formula (1) characterized in that: (a) an oxazolidine derivative represented by formula (2) or its salt in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III represented by formula (3) in which R1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane represented by formula (4) in which X and R1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hydroxy group at 7-position is protected with trihaloacetyl group represented by formula (5) in which R1 is as previously defined; (c) then the protecting group at 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent. |
| priorityDate |
1996-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |