| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f34119b232d292c72e632b62008eca90 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-128
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0029 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 |
| filingDate |
1996-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_504a7b3e0fe2f6c13f10728f49d3535b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8564e28b5332f20d228e01b471d4b500
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8adaa0da466fd14492538cdf56da28dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9fcca2e9eb2e5161f5655cad00c7519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbb93420b8bbe53636391f6bdd53680c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61821add5a90e50620ccdccf0e3f9e52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d6184797735b930194edddbcfbf80cb |
| publicationDate |
1999-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0923390-A1 |
| titleOfInvention |
Method for making improved heparinized biomaterials |
| abstract |
A method of making a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophylactic properties of ATIII/heparin are obtained. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7094220-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7311698-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10441454-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7682353-B2 |
| priorityDate |
1995-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |