| abstract |
Imidazole-substituted quinoxalinedione derivativesnrepresented by the following general formula (I) ornpharmaceutically acceptable salts thereof and pharmaceuticalncompositions useful as glutamate receptor antagonists and thenlike, which comprise said compounds or salts thereof andnpharmaceutically acceptable carriers.n n(Each symbol in the formula has the following meaning:n A: a group represented by a formula (CH 2 ) m or a group representednby a formula Ph-(CH 2 ) p (Ph: a phenyl group), X: an oxygen atom or a group represented by a formula NR 4 , R 1 : a hydrogen atom, a hydroxyl group or a triazolyl group,nwith the proviso that X may be a bond when R 1 is a triazolylngroup, R 2 : a hydrogen atom, a nitro group, a halogeno-lower alkyl group,na cyano group, an amino group, a mono- or di-lower alkylaminongroup or a halogen atom, R 3 and R 4 : may be the same or different from each other and eachnrepresents a hydrogen atom or a lower alkyl group, n: 0, 1 or 2, m: an integer of 2 to 6, and p: an integer of 1 to 6.) |