| abstract |
The present invention provides an effective and industrially advantageous process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine which are used as materials for pharmaceuticals such as antiviral agents and the like, and particularly as materials for antisense drugs. The present invention provides (1) A process for effectively producing 2,6-diaminopurine-2'-deoxyriboside by putting 2'-deoxyribose-1-phosphoric acid or a salt thereof and 2,6-diaminopurine or a salt thereof under the action of a microorganism. (2) A process for effectively producing 2,6-diaminopurine-2'-deoxyriboside by putting 2'-deoxyuridine or thymidine and 2,6-diaminopurine or a salt thereof under the action of a microorganism in the presence of an inorganic phosphoric acid or a salt thereof. (3) A process for producing 2'-deoxyguanosine in a high yield by putting 2,6-diaminopurine-2'-deoxyriboside, used as a substrate, produced and provided steadily and at low costs by the processes according to (1) and (2) described above, under the action of adenosine deaminase. |