http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0915872-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 1997-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b18d2f52d1f742f912a2ffdbcfdc578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a734d142ddc8bf5367983caae1ff9fa3 |
| publicationDate | 1999-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0915872-A1 |
| titleOfInvention | Substituted bisindolylmaleimides for the inhibition of cell proliferation |
| abstract | Compounds of formula (I) wherein R?1 and R1'¿ are independently alkyl, aryl, alkenyl or alkynyl; R?2 and R2'¿ are independently hydrogen or alkyl; R?4, R5, R6 and R7¿ each independently are (a), CO¿2R?9, CH2OR10, CHO, CH¿2?NR?11R12, CON(R13)¿2, hydrogen, halogen, cyano, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino, acylamino, aralkyloxy, monoalkylamino, dialkylamino, alkylthio, alkylsulphinyl or alkylsulphonyl, provided that at least one of R?4, R5, R6 or R7¿ is cyano, (a), CO¿2R?9, CH2OR10, CH2NR11R12, CHO or CON(R13)2; R8 is alkyl, aralkyl or aryl; R9 is alkyl, aralkyl or aryl; R10 is hydrogen, alkyl, aralkyl or aryl; R?11 and R12¿ are independently hydrogen, alkyl, aryl, aralkyl or acyl; R13 is hydrogen, alkyl, aryl or aralkyl; and one of X and Y signifies O and the other signifies O, S, (H,OH) or (H,H); as well as pharmaceutically acceptable prodrugs or salts of acidic compounds of formula (I) with bases and or basic compounds of formula (I) with acids are antiproliferative agents useful in the treatment of cancer. |
| priorityDate | 1996-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.